Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 51, Issue 4, Pages 1563-1565Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01326-06
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Funding
- NIAID NIH HHS [UC1 AI049514, AI-049514-01, R43 AI060250-01, R43 AI060250] Funding Source: Medline
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Substitution of the new diamine antibiotic SQ109 for ethambutol in a mouse model of chronic tuberculosis (TB) improved efficacy of combination drug therapy with first-line TB drugs rifampin and isoniazid, with or without pyrazinamide: at 8 weeks, lung bacteria were 1.5 log(10) lower in SQ109-containing regimens.
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