Journal
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
Volume 22, Issue 2, Pages 161-171Publisher
SPRINGER
DOI: 10.1007/s10827-006-0005-7
Keywords
inward rectifier; reliability; information theory; spike-triggered covariance; principal component analysis; single-neuron computation
Funding
- NIMH NIH HHS [R01 MH61604] Funding Source: Medline
- NINDS NIH HHS [R01 NS34425] Funding Source: Medline
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Stellate cells (SCs) of the entorhinal cortex generate prominent subthreshold oscillations that are believed to be important contributors to the hippocampal theta rhythm. The slow inward rectifier I-h is expressed prominently in SCs and has been suggested to be a dominant factor in their integrative properties. We studied the input-output relationships in stellate cells (SCs) of the entorhinal cortex, both in control conditions and in the presence of the I-h antagonist ZD7288. Our results show that I-h is responsible for SCs' subthreshold resonance, and contributes to enhanced spiking reliability to theta-rich stimuli. However, SCs still exhibit other traits of rhythmicity, such as subthreshold oscillations, under I (h) blockade. To clarify the effects of I-h on SC spiking, we used a generalized form of principal component analysis to show that SCs select particular features with relevant temporal signatures from stimuli. The spike-selected mix of those features varies with the frequency content of the stimulus, emphasizing the inherent nonlinearity of SC responses. A number of controls confirmed that this selectivity represents a stimulus-induced change in the cellular input-output relationship rather than an artifact of the analysis technique. Sensitivity to slow features remained statistically significant in ZD7288. However, with I-h blocked, slow stimulus features were less predictive of spikes and spikes conveyed less information about the stimulus over long time scales. Together, these results suggest that I-h is an important contributor to the input-output relationships expressed by SCs, but that other factors in SCs also contribute to subthreshold oscillations and nonlinear selectivity to slow features.
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