4.2 Article

Microwave-assisted RCM for the synthesis of carbocyclic peptides

Journal

JOURNAL OF PEPTIDE SCIENCE
Volume 13, Issue 4, Pages 280-285

Publisher

JOHN WILEY & SONS LTD
DOI: 10.1002/psc.840

Keywords

microwave; ring closing metathesis; dicarba peptides; conotoxins

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Microwave irradiation dramatically improves the efficiency of ring closing metathesis (RCM) reactions of resin-attached peptides and the technology is illustrated by the highly selective synthesis of dicarba analogues of alpha-conotoxin IMI. Copyright (C) 2007 European Peptide Society and John Wiley & Sons, Ltd.

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