Journal
NEUROSCIENTIST
Volume 13, Issue 2, Pages 109-114Publisher
SAGE PUBLICATIONS INC
DOI: 10.1177/1073858406296407
Keywords
cannabinoids; neurogenesis; neural progenitors; brain diseases
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The endocannabinoid system exerts an important neuromodulatory function in different brain areas and is also known to be involved in the regulation of neural cell fate. Thus, CB1 cannabinoid receptors are neuroprotective in different models of brain injury, and their expression is altered in various neurodegenerative diseases. Recent findings have demonstrated the presence of a functional endocannabinoid system in neural progenitor cells that participates in the regulation of cell proliferation and differentiation. In this Research Update, the authors address the experimental evidence regarding the regulatory role of cannabinoids in neurogenesis and analyze them in the context of those pathological disorders in which cannabinoid function and altered neuronal or glial generation is most relevant, for example, stroke and multiple sclerosis.
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