Journal
NEUROBIOLOGY OF AGING
Volume 28, Issue 4, Pages 519-523Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2006.02.011
Keywords
Alzheimer's disease; genetic risk factor; TAP; APOE; interaction
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Sporadic Alzheimer's disease (AD) appears to be the consequence of the interaction between combinations of genes and environmental factors. Binding with the transporter associated with antigen processing (TAP) is thought to be the main way in which herpes simplex virus type 1 (HSV-1) evades immune surveillance. Several TAP gene polymorphisms were examined and a TAP2 SNP (rs241448) associated with AD found in two independent case-control samples, especially in carriers of the APOE4 allele. These findings are consistent with the hypothesis that human genetic variants facilitating the access of HSV-1 to the brain might result in susceptibility to AD. (c) 2006 Elsevier Inc. All rights reserved.
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