Journal
TRENDS IN GENETICS
Volume 23, Issue 4, Pages 154-157Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tig.2007.02.009
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- NCI NIH HHS [CA051704] Funding Source: Medline
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Cancers are thought to originate in stem cells through the accumulation of multiple mutations. Some of these mutations result in a loss of heterozygosity (LOH). A recent report demonstrates that exposure of mouse embryonic stem cells to nontoxic amounts of mutagens triggers a marked increase in the frequency of LOH. Thus, mutagen induction of LOH in embryonic stem cells suggests a new pathway to account for the multiple homozygous mutations in human tumors. This induction could mimic early mutagenic events that generate cancers in human tissue stem cells.
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