Journal
PHYTOCHEMISTRY
Volume 68, Issue 7, Pages 1068-1074Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2007.01.006
Keywords
amaryllidaceae; apoptosis-induction; anticancer agent; alkaloid
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The selective apoptosis-inducing activity of Amaryllidaceae alkaloids belonging to the crinane-type is reported. A mini-library of natural and synthetic crinane alkaloids was assembled. Biological screening indicated crinamine 4 and haemanthamine 9 to be potent inducers of apoptosis in tumour cells at micromolar concentrations. Structure-activity relationships demonstrated the requirement for both an alpha-C2 bridge and a free hydroxyl at the C-11 position as pharmacophoric requirements for this activity. (C) 2007 Elsevier Ltd. All rights reserved.
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