Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 17, Issue 2, Pages 192-198Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.sbi.2007.03.004
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Funding
- Division Of Chemistry
- Direct For Mathematical & Physical Scien [1047323] Funding Source: National Science Foundation
- NIGMS NIH HHS [GM063796, 5 F32 GM076839-02] Funding Source: Medline
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Considerable progress has been recently achieved in the multiscale modeling of complex biological processes. Multiscale models have now investigated the structure and dynamics of lipid membranes, proteins, peptides and DNA over length and time scales ranging from the atomic to the macroscopic. Serial multiscale methods that parameterize low-resolution coarse-grained models with data from high-resolution models have studied long time or length scale phenomena that cannot be investigated with atomically detailed models. Parallel multiscale methods that directly couple high- and low-resolution models have efficiently explored slow structural transitions and the importance of long-wavelength fluctuations for biological molecules. The success of such models relies upon new theories and methods for constructing accurate multiscale bridges that transfer information between models with different resolutions.
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