Journal
JOURNAL OF INORGANIC BIOCHEMISTRY
Volume 101, Issue 4, Pages 686-691Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jinorgbio.2006.11.018
Keywords
nano-hydroxyapatite; gelatin; composite microspheres; one-pot; emulsion
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A one-pot strategy was first presented in this paper to synthesize gelatin/hydroxyapatite (HAP) composite microspheres in a water-in-oil (W/O) emulsion. Using gelatin droplets as microreactors and colloid protective medium, needle-like nano-HAP crystals (5 nm x 60-100 nm) in form of clusters were homogeneously and orderly precipitated within gelatin matrix. The results of scanning electron microscopy (SEM) revealed that the as-prepared microspheres with an average diameter of 7.5 mu m displayed a narrow particle size distribution, a high dispersity and a naturally porous structure. This microsphere material is expected to have a great potential for both controlled drug release and faster bone in-growth in bone tissue engineering. (c) 2006 Elsevier Inc. All rights reserved.
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