Journal
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
Volume 81A, Issue 1, Pages 59-65Publisher
WILEY
DOI: 10.1002/jbm.a.31003
Keywords
angiogenesis; adipogenesis; collagen; chitosan; regenerative medicine
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A portfolio of crosslinked chitosan:collagen blends was prepared, and their microarchitecture and water binding capacity were studied to investigate their application for adipose tissue engineering. Glutaraldehyde (GA) concentration had little effect on scaffold morphology or water binding capacity. However, the processing freezing temperature prior to lyophilization affected both. In vitro cytocompatibility of preadipocytes (PAs) was assessed for a candidate collagen:chitosan blend using two assays. Results confirm the viability of PAs on GA-crosslinked collagen:chitosan scaffolds. A rat subcutaneous pocket assay was employed to assess PA-seeded scaffolds in vivo. Animal tests proved that PA-seeded scaffolds were biocompatible, could induce vascularization, and form adipose tissue. (c) 2006 Wiley Periodicals, Inc. J Biomed Mater Res 81A: 59-65, 2007.
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