Journal
CANCER CHEMOTHERAPY AND PHARMACOLOGY
Volume 59, Issue 5, Pages 637-642Publisher
SPRINGER
DOI: 10.1007/s00280-006-0306-6
Keywords
capecitabine; chemotherapy; neuroendocrine tumours; oxaliplatin; XELOX
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The aim of this trial was to evaluate the safety and efficacy of oxaliplatin and capecitabine (XELOX) in neuroendocrine tumours' (NETs) treatment. Forty patients (pts) with advanced NETs were treated. Of these, 13 had untreated poorly differentiated NETs, 27 had well-differentiated NETs in progression after somatostatin analogues. Patients received oxaliplatin e.v. 130 mg/mq i.v. and capecitabine 2,000 mg/mq/die. The primary sites of the disease were: lung (10 pts), pancreas (15 pts), small bowel (8 pts), unknown (1 pt), others (6 pts). In 13 pts with poorly differentiated NETs objective responses (OR) were: 3 PR (23%), 1 SD (7%), 9 PD (70%). Biochemical responses were 11%. In 27 patients with well-differentiated NETs the OR were: 8 PR (30%), 13 SD (48%) and 6 PD (22%). Biochemical and symptomatic responses were 20 and 50%, respectively. The XELOX regimen is effective and tolerated in well-differentiated NETs after progression following somatostatin analogues.
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