Journal
INTERNATIONAL JOURNAL OF CANCER
Volume 120, Issue 7, Pages 1444-1450Publisher
WILEY
DOI: 10.1002/ijc.22476
Keywords
CD133; hepatocellular carcinoma; tumorigenicity
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Recently increasing reported data have suggested that only a small subset of cancer cells possess capability to initiate malignancies including leukemia and solid tumors, which was based on investigation in these cells displaying a distinct surface marker pattern within the primary cancers. CD133 is a putative hematopoietic and neuronal stem-cell marker, which was also considered as a tumorigenic marker in brain and prostate cancer. We hypothesized that CD133 was a marker closely correlated with tumorigenicity, since it was reported that CD133 expressed in human fetal liver and repairing liver tissues, which tightly associated with hepatocarcinogenesis. Our findings showed that a small population of CD133 positive cells indeed exists in human hepatocellular carcinoma (HCC) cell lines and primary HCC tissues. From SMMC-7721 cell line, CD133(+) cells isolated by MACS manifested high tumorigenecity and clonogenicity as compared with CD133(-) HCC cells. The implication that CD133 might be one of the markers for HCC cancer stem-like cells needed further investigation. (c) 2007 Wiley-Liss, Inc.
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