Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 19, Issue 2, Pages 117-123Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/j.ceb.2007.02.010
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Funding
- NCI NIH HHS [R01 CA058530-13, R01 CA058530, CA058530] Funding Source: Medline
- NIDDK NIH HHS [R01 DK052916, DK052916] Funding Source: Medline
- NINDS NIH HHS [NS053414, R01 NS053414] Funding Source: Medline
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Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands - mainly growth factors - play key roles in processes such as cellular growth, differentiation, metabolism and motility. Recent progress has been achieved towards an understanding of the precise (and varied) mechanisms by which RTKs are activated by ligand binding and by which signals are propagated from the activated receptors to downstream targets in the cell.
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