Journal
RNA
Volume 13, Issue 4, Pages 463-467Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1261/rna.296407
Keywords
A-to-I RNA editing; microRNA repression; microRNA target sites; tissue specificity
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Funding
- NIGMS NIH HHS [GM59708, R01 GM059708] Funding Source: Medline
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Adenosine (A) to inosine (I) RNA editing occurs widely in the human transcriptome, and a large proportion of editing sites are within untranslated regions (UTRs). MicroRNAs (miRNAs), an abundant class of regulatory genes, specify the expression of a large number of target genes by pairing to their 39 UTRs. To study the interplay between these two post-transcriptional events, we developed a computational pipeline to integrate sequence and miRNA tissue specificity data. The results show that some A-to-I RNA editing positions have a potential to block the miRNA: target recognition, although further computational simulation suggests that RNA editing tends to avoid miRNA target sites in general. We propose that a small proportion of RNA editing events may provide an additional layer of control on miRNA-mediated repression. Further investigation is needed to elucidate the functional effect of these special RNA editing events.
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