Journal
PAIN
Volume 128, Issue 3, Pages 209-214Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1016/j.pain.2006.09.017
Keywords
substance P; calcitonin gene-related peptide (CGRP); angiotensin converting enzyme (ACE); migraine; headache
Categories
Ask authors/readers for more resources
Substance P (SP), calcitonin gene-related peptide (CGRP), and angiotensin converting enzyme (ACE) may have roles in trigeminovascular nociceptive mechanisms. We investigated interictal levels of SP, CGRP, ACE activity, and their correlation, in a sample of migraineurs. Forty-one patients suffering from migraine with aura (MA), 54 without aura (MO), and 52 non-headache subjects (controls) participated in this Study. Blood samples were collected from cubital veins. Plasma levels of SP and CGRP were measured by enzyme immunoassay. Plasma ACE activities were measured spectrophotometrically. SP levels in MA (6.6 +/- 3.7 pg/ml; mean +/- SD) and MO (6.6 +/- 3.2 pg/ml) were significantly higher than in controls (4.8 +/- 2.4 pg/ml) (P < 0.01). CGRP levels in MA (18.8 +/- 8.8 pg/ml) and MO (19.1 +/- 9.4 pg/ml) were also significantly higher than in controls (13.4 +/- 4.4 pg/ml) (P < 0.01). ACE activities in MA (34.6 +/- 19.0 U/l) were significantly higher than in MO (25.3 +/- 13.2 U/l) and controls (27.0 +/- 20.4 U/l) (P < 0.05). There was a significant correlation between SP and CGRP levels (P < 0.05). In MA, SP and CGRP showed a tendency toward positive correlation, which was not significant. There was a weak, but significant positive correlation between SP levels and ACE activities (P < 0.01). However, a relationship between ACE activities and CGRP levels was not observed. The data Suggest that SP, CGRP, and ACE are relevant to migraine pathophysiology, and that they may interact. (c) 2006 International Association for the Study of Pain. Published by Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available