Journal
INTERNATIONAL JOURNAL FOR PARASITOLOGY
Volume 37, Issue 5, Pages 475-482Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ijpara.2006.12.013
Keywords
patch-clamp; ion channels; new permeability pathways; PSAC; plasmodium; oxidation
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Funding
- Intramural NIH HHS [Z01 AI000882-07] Funding Source: Medline
- Wellcome Trust [076441] Funding Source: Medline
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The altered permeability characteristics of erythrocytes infected with malaria parasites have been a source of interest for over 30 years. Recent electrophysiological studies have provided strong evidence that these changes reflect transmembrane transport through ion channels in the host erythrocyte plasma membrane. However, conflicting results and differing interpretations of the data have led to confusion in this field. In an effort to unravel these issues, the groups involved recently came together for a week of discussion and experimentation. In this article, the various models for altered transport are reviewed, together with the areas of consensus in the field and those that require a better understanding. (c) 2007 Australian Society for Parasitology Inc. Published by Elsevier Ltd. All rights reserved.
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