Journal
JOURNAL OF VIROLOGY
Volume 81, Issue 7, Pages 3627-3631Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02786-06
Keywords
-
Categories
Funding
- Biotechnology and Biological Sciences Research Council [BB/E02145X/1] Funding Source: researchfish
- Biotechnology and Biological Sciences Research Council [BB/E02145X/1] Funding Source: Medline
- BBSRC [BB/E02145X/1] Funding Source: UKRI
Ask authors/readers for more resources
Recent evidence supports a role for vitamin K-dependent coagulation zymogens in adenovirus serotype 5 (Ad5, subgroup C) infection of hepatocytes. Here, we assessed the effect of virus-zymogen interaction on cellular transduction using a panel of fiber (f)-pseudotyped viruses derived from subgroup D (f47, f33, f24, f45, f17, f30). Each virus directly bound factor X (FX) as determined by surface plasmon resonance, resulting in enhanced cell surface binding. Infection of HepG2 cells was promoted by FX but not by FVII or FIX, while transduction of CHO cells was blocked in heparan sulfate proteoglycan-deficient cells. This suggests a broad role for FX in adenovirus infectivity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available