Journal
INTERNATIONAL JOURNAL OF PSYCHOPHYSIOLOGY
Volume 64, Issue 1, Pages 3-17Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ijpsycho.2006.08.004
Keywords
EEG; Mu rhythm; dendrites; metabotropic glutamate receptor; gap junctions
Funding
- Wellcome Trust [078403, 078311, 071436] Funding Source: Medline
Ask authors/readers for more resources
Rhythms in the a frequency band (8-13 Hz) are a defining feature of the human EEG during relaxed wakefulness and are known to be influenced by the thalamus. In the early stages of sleep and in several neurological and psychiatric conditions a rhythms are replaced by slower activity in the theta (3-7 Hz) band. Of particular interest is how these alpha and theta rhythms are generated at the cellular level. Recently we identified a subset of thalamocortical (TC) neurons in the lateral geniculate nucleus (LGN) which exhibit rhythmic high-threshold (>-55 mV) bursting at similar to 2-13 Hz and which are interconnected by gap junctions (GJs). These cells combine to generate a locally synchronized continuum of alpha and theta oscillations, thus providing direct evidence that the thalamus can act as an independent pacemaker of alpha and theta rhythms. Interestingly, GJ coupled pairs of TC neurons can exhibit both in-phase and anti-phase synchrony and will often spontaneously alternate between these two states. This dictates that the local field oscillation amplitude is not simply linked to the extent of cell recruitment into a single synchronized neuronal assembly but also to the degree of destructive interference between dynamic, spatially overlapping, competing anti-phase groups of continuously bursting neurons. Thus, the waxing and waning of thalamic alpha/theta rhythms should not be assumed to reflect a wholesale increase and reduction, respectively, in underlying neuronal synchrony. We argue that these network dynamics might have important consequences for relating changes in the amplitude of EEG alpha and theta rhythms to the activity of thalamic networks. (c) 2006 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available