Journal
PROSTATE
Volume 67, Issue 5, Pages 536-546Publisher
WILEY
DOI: 10.1002/pros.20549
Keywords
prostate cancer; T cells; transgenic mice; dendritic cells; T regulatory cells
Categories
Funding
- NCI NIH HHS [CA109339, R01 CA109339-03, R01 CA109339] Funding Source: Medline
- NIAID NIH HHS [R01 AI057441, R56 AI057441, AI057441, R01 AI057441-03] Funding Source: Medline
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BACKGROUND. Prostate cancer promotes the development of T cell tolerance towards prostatic antigens, potentially limiting the efficacy of prostate cancer vaccines targeting these antigens. Here, we sought to determine the stage of disease progression when T cell tolerance develops, as well as the role of steady state dendritic cells (DC) and CD4(+)CD25(+) T regulatory cells (Tregs) in programming tolerance. METHODS. The response of naive HA-specific CD4(+) T cells were analyzed following adoptive transfer into Pro-HA x TRAMP transgenic mice harboring variably-staged HA-expressing prostate tumors on two genetic backgrounds that display different patterns and kinetics of tumorigenesis. The role of DC and Tregs in programming HA-specific CD4 cell responses were assessed via depletion. RESULTS. HA-specific CD4 cells underwent non-immunogenic responses at all stages of tumorigenesis in both genetic backgrounds. These responses were completely dependent on DC, but not appreciably influenced by Tregs. CONCLUSIONS. These results suggest that tolerogenicity is an early and general property of prostate tumors.
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