Journal
GENES & DEVELOPMENT
Volume 21, Issue 7, Pages 744-749Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.1519107
Keywords
miR-124; SCP1; neural tube development; neurogenesis
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Funding
- NICHD NIH HHS [P30 HD024064, P30 HD24064] Funding Source: Medline
- NINDS NIH HHS [R01 NS054941] Funding Source: Medline
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Neuronal gene expression is tightly regulated in developing CNS. Here, we demonstrate the anti-neural function of phosphatase SCP1 (small C-terminal domain phosphatase 1) during development. We further show that the neuron-enriched microRNA miR-124 directly targets SCP1-3' untranslated region (UTR) to suppress SCP1 expression. In developing spinal cord, expression of miR-124 and SCP1 is complementary, and miR-124 antagonism phenocopies SCP1 overexpression and vice versa. In P19 cells, miR-124 suppresses SCP1 expression and induces neurogenesis, and SCP1 counteracts this proneural activity of miR-124. Our results suggest that, during CNS development, timely down-regulation of SCP1 is critical for inducing neurogenesis, and miR-124 contributes to this process at least in part by down- regulating SCP1 expression.
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