Journal
JOURNAL OF VIROLOGY
Volume 81, Issue 7, Pages 3640-3644Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.02254-06
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Funding
- NCI NIH HHS [R01 CA094809, CA 088768, CA 094809, R01 CA088768] Funding Source: Medline
- NIDDK NIH HHS [R90 DK 071505, R90 DK071505] Funding Source: Medline
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Genetic and biochemical studies have suggested the existence of a bacteriophage-like, DNA-packaging/ ejecting portal complex in herpesviruses capsids, but its arrangement remained unknown. Here, we report the first visualization of a unique vertex in the Kaposi's sarcoma-associated herpesvirus (KSHV) capsid by cryoelectron tomography, thus providing direct structural evidence for the existence of a portal complex in a gammaherpesvirus. This putative KSHV portal is an internally localized, umbilicated structure and lacks all of the external machineries characteristic of portals in DNA bacteriophages.
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