Journal
HAEMATOLOGICA
Volume 92, Issue 4, Pages 542-545Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.10758
Keywords
histone deacetylase inhibitor; CD34(+) leukemic progenitor cells; interphase FISH; AML1/ETO; AML blast colonies
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Funding
- Alfred und Angelika Gutermuth-Stiftung
- Deutsche Jose Carreras Leukamie-Stiftung [R04/05]
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Histone deacetylase inhibitor valproic acid (VPA) was recently shown to enhance proliferation and self-renewal of normal hematopoietic stem cells, raising the possibility that VPA may also support growth of leukemic progenitor cells (LPC). Here, VPA maintains a significantly higher proportion of CD34(+) LPC and colony forming units compared to control cultures in six AML samples, but selectively reduces leukemic cell numbers in another AML sample with expression of AML1/ETO. Our data suggest a differential effect of VPA on the small population of AML progenitor cells and the bulk of aberrantly differentiated blasts in the majority of AML samples tested.
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