Journal
ALZHEIMERS & DEMENTIA
Volume 3, Issue 2, Pages 122-125Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.jalz.2007.01.019
Keywords
myelin; oligodendrocyte; white matter; amyloid; iron; Alzheimer's disease; PIB; degeneration; dementia; aging; medications; treatment; prevention
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Funding
- NIA NIH HHS [P50 AG016570-06, R01 AG027342, P50 AG016570] Funding Source: Medline
- NIMH NIH HHS [R01 MH066029-01A2, R01 MH066029] Funding Source: Medline
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We hypothesized that myelin breakdown in vulnerable late-myelinating regions releases oligodendrocyte- and myelin-associated iron that promotes amyloid beta (A beta) oligornerization, its associated toxicity, and the deposition of oligomerized A beta and iron in neuritic plaques observed in Alzheimer's disease (AD). The model was tested by using published maps of cortical myelination from 1901 and recent in vivo imaging maps of A beta deposits in humans. The data show that in AD, radiolabeled ligands detect A beta deposition in a distribution that matches the map of late-myelinating regions. Furthermore, the strikingly lower ability of this imaging ligand to bind A beta in animal models is consistent with the much lower levels of myelin and associated iron levels in rodents when compared with humans. The hypotheses derived from the myelin model are testable with current imaging methods and have important implications for therapeutic interventions that should be expanded to include novel targets such as oligodendrocytes, myelin, and brain iron. (c) 2007 The Alzheimer's Association. All rights reserved.
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