Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 42, Issue 4, Pages 487-493Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2006.11.002
Keywords
nucleoside; antiviral agent; Simmons-Smith cyclopropanation
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A series of novel fluorocyclopropyl nucleosides were synthesized starting from acetol using the Simmons-Smith reaction as a key reaction. All the nucleosides synthesized were assayed against several viruses. Among the compounds synthesized, the uracil analogue 22 showed moderate anti-HCMV activity (10.61 mu g/mL, in AD-169). (c) 2006 Elsevier Masson SAS. All rights reserved.
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