Journal
JOURNAL OF COMPUTATIONAL NEUROSCIENCE
Volume 22, Issue 2, Pages 211-222Publisher
SPRINGER
DOI: 10.1007/s10827-006-0008-4
Keywords
lactotrophs; bursting; calcium; fast; slow analysis
Funding
- NIDA NIH HHS [DA-19356, R01 DA019356] Funding Source: Medline
- NIDDK NIH HHS [DK-43200, R01 DK043200] Funding Source: Medline
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Dopamine (DA) released from the hypothalamus tonically inhibits pituitary lactotrophs. DA (at micromolar concentration) opens potassium channels, hyperpolarizing the lactotrophs and thus preventing the calcium influx that triggers prolactin hormone release. Surprisingly, at concentrations similar to 1000 lower, DA can stimulate prolactin secretion. Here, we investigated whether an increase in a K+ current could mediate this stimulatory effect. We considered the fast K+ currents flowing through large-conductance BK channels and through A-type channels. We developed a minimal lactotroph model to investigate the effects of these two currents. Both I (BK) and I (A) could transform the electrical pattern of activity from spiking to bursting, but through distinct mechanisms. I (BK) always increased the intracellular Ca2+ concentration, while I-A could either increase or decrease it. Thus, the stimulatory effects of DA could be mediated by a fast K+ conductance which converts tonically spiking cells to bursters. In addition, the study illustrates that a heterogeneous distribution of fast K+ conductances could cause heterogeneous lactotroph firing patterns.
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