Journal
EUROPEAN JOURNAL OF CANCER
Volume 43, Issue 6, Pages 1066-1075Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.ejca.2007.01.013
Keywords
melanoma; pesticides; case-control; household
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Occupational pesticide exposure has been linked to cutaneous melanoma in epidemiological studies. We studied the association between cutaneous melanoma and the residential use of pesticides. This is a case-control study of cutaneous melanoma (287 incident cases; 299 controls). Data on pesticide use was obtained with a standardised interview. An increased risk of melanoma was found for high use (>= 4 times annually) of indoor pesticides (odds ratio (OR) = 2.18; 95% confidence intervals (CI) 1.07-4.43) compared to low use (<= 1 times annually), after adjustment for sex, age, education, sun exposure and pigmentary characteristics. Subjects exposed for 10 years or more had two and a half times the risk (OR = 2.46; 95% CI 1.23-4.94) of those exposed for less than 10 years. A dose response was observed for the intensity of pesticides use (p(trend) = 0.027). The results indicate that residential pesticide exposure may be an independent risk factor for cutaneous melanoma. (C) 2007 Elsevier Ltd. All rights reserved.
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