Journal
BIOORGANIC & MEDICINAL CHEMISTRY
Volume 15, Issue 7, Pages 2601-2610Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bmc.2007.01.043
Keywords
thiazole; triazole; cdk5/p25; Alzheimer's disease
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A novel clubbed triazolyl thiazole series of cdk5/p25 inhibitors, potentially useful for the treatment of Alzheimer's disease, is disclosed. Evaluation of the SAR of substitution within these series has allowed the identification of a range of compounds which significantly reduce brain cdk5/p25 and thus have potential as possible treatments for Alzheimer's disease. (c) 2007 Elsevier Ltd. All rights reserved.
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