Journal
FASEB JOURNAL
Volume 21, Issue 4, Pages 1107-1116Publisher
FEDERATION AMER SOC EXP BIOL
DOI: 10.1096/fj.06-6802com
Keywords
antimicrobial peptides; cathelicidin; complement
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Funding
- NIAID NIH HHS [AI-48176, AI-048694] Funding Source: Medline
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Antibiotics are designed to support host defense in controlling infection. Here we describe a paradoxical inhibitory effect of bacteriostatic antibiotics on key mediators of mammalian innate immunity. When growth of species including Escherichia coli and Staphylococcus aureus is suppressed by chloramphenicol or erythromycin, the susceptibility of the bacteria to cathelicidin antimicrobial peptides or serum complement was markedly diminished. Survival of the bacteria in human whole blood, human wound fluid, or a mouse wound infection model was in turn increased after antibiotic-induced bacteriostasis. These findings provide a further rationale against the indiscriminate use of antibiotics.
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