Journal
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE
Volume 143, Issue 4, Pages 422-425Publisher
SPRINGER
DOI: 10.1007/s10517-007-0146-3
Keywords
platelets; spontaneous aggregation; glycoprotein IIb-IIIa; glycoprotein Ib; genetic polymorphism
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In some patients with stable and unstable angina pectoris and in some donors without clinical manifestations of cardiovascular diseases and other pathologies, spontaneous platelet aggregation was completely suppressed by glycoprotein IIb-IIIa antagonists blocking the interaction of this glycoprotein with fibrinogen. Antibodies inhibiting binding of glycoprotein Ib with von Willebrand factor had no effect on the level and rate of spontaneous platelet aggregation. In the donor group, the level of spontaneous aggregation was almost 1.5-fold higher in persons with a certain genetic polymorphism (Leu -> Pro substitution in position 33 of glycoprotein IIIa). The level of spontaneous aggregation correlated with the amount of glycoprotein IIb-IIIa on the platelet surface (r=0.41)
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