Journal
JOURNAL OF NATURAL PRODUCTS
Volume 70, Issue 4, Pages 538-543Publisher
AMER CHEMICAL SOC
DOI: 10.1021/np060450q
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Four bis-piperidine alkaloids, madangamine F (1), haliclonacyclamine F (2). and arenosclerins D (3) and E (4), have been isolated from the marine sponge Pachychalina alcaloidifera and have been identified by analysis of spectroscopic data. The alkaloids displayed cytotoxic activity against different cancer cell lines. These results support the hypothesis of a common biogenetic origin for the Haplosclerida bis-piperidine and bis-pyridine alkaloids.
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