Journal
CHEMICAL & PHARMACEUTICAL BULLETIN
Volume 55, Issue 4, Pages 651-654Publisher
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.55.651
Keywords
thalidomide; hydrolyzed thalidomide; metabolite; tumor necrosis factor (TNF)-alpha modulator
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Putative hydrolyzed metabolites of thalidomide were prepared and characterized, and their inhibitory activity on tumor necrosis factor (TNF)-alpha production in the human monocytic leukemia cell line THP-1 was evaluated. alpha-(2-Carboxybenzamido)glutarimide was a more potent TNF-alpha production inhibitor than thalidomide.
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