Journal
PET CLINICS
Volume 2, Issue 2, Pages 125-160Publisher
ELSEVIER INC
DOI: 10.1016/j.cpet.2007.12.001
Keywords
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Funding
- National Institutes of Health [R01CA119056, R01EB120474, R33 EB003283, R21 CA098691]
- California Breast Cancer Research Program [12IB-0092]
- Stanford University Bio-X Graduate Program
- Society of Nuclear Medicine
- NVIDIA Corporation Research Fellowship Program
- Swiss National Foundation [SNSF 3100A0-116547]
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PET is used in laboratory small-animal research to visualize and track certain molecular processes associated with diseases such as cancer, heart disease, and neurologic disorders in living small-animal models of disease. The current and next generation of PET molecular imaging probes, assays, and imaging systems still have substantial room to improve PET's ability to detect, visualize, and quantify low concentrations of probe interacting with its target, which we refer to as the molecular sensitivity. This article focuses on the challenges of advancing PET system and some of the new imaging system technologies under investigation to enhance PET's molecular sensitivity substantially.
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