Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 311, Issue 1, Pages 244-248Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2006.10.1154
Keywords
bio chip; DNA; microarray; hybridization; magnetic; microparticle; fluorescence analysis; mixing; liquid film
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In classical DNA chip analysis, the target DNA moves by diffusion and Brownian motion only. We introduce a system for enhancing the signals and reducing the hybridization times of bio chips. It allows active agitation within the hybridization buffer by controlled movement of magnetic particles within the analyte solution. First results show that the system easily achieves specific fluorescent signals about four times higher than the ones obtained by a referencing standard procedure within the same hybridization time, while unspecific signals remain unchanged. The device can easily be applied to existing bio chip applications and allows universal operation in the field of molecular diagnostics. (C) 2006 Elsevier B.V. All rights reserved.
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