Oxidation-stable linoleic acid by inclusion in α-cyclodextrin

Linoleic acid is essential to the skin's barrier function. Its skin-care and restorative properties make it attractive for use in cosmetics and dermatology. However, its sensitivity to oxidation and tendency to go rancid prevent its use in cosmetic preparations. But in the form of a molecular inclusion compound with alpha-cyclodextrin, linoleic acid is effectively protected against oxidation. Investigations into the storage and light stability, olfactory tests and headspace analysis of the formulations give evidence of the stability of a suitable inclusion compound. Reversible complexation makes it possible for the first time to use linoleic acid in various cosmetic formulations and personal-care products.