Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 311, Issue 1, Pages 464-468Publisher
ELSEVIER
DOI: 10.1016/j.jmmm.2006.10.1188
Keywords
MRI; enhanced ferrite; iron nanoparticle
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Enhanced ferrite nanoparticles are a new class of contrast agents for magnetic resonance imaging (MRI). The enhanced ferrites, are synthesized by reverse micelles technique to form iron core and oxide or ferrite shell preventing further oxidation of the nanoparticles. The nanoparticles are further functionalized using dopamine and PEG-600 to increase the solubility of the high magnetic moment nanoparticles. H-1 relaxation measurements of aqueous solutions of the nanoparticles were conducted at 2.4T. The relaxivities r(1) and r(2), representing the slopes of these curves, are 7.19 and 9.96 s(-1) mM(-1), respectively. These values should be compared with relaxivities of 4-5 s(-1) mM(-1) corresponding to commonly used commercial contrast agents in human MR examinations. (C) 2006 Published by Elsevier B.V.
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