Journal
CYTOTECHNOLOGY
Volume 53, Issue 1-3, Pages 23-31Publisher
SPRINGER
DOI: 10.1007/s10616-007-9052-9
Keywords
Chinese hamster ovary; NS0; proteomics; high cell productivity
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Global expression profiling of mammalian cells used for the production of biopharmaceuticals will allow greater insights into the molecular mechanisms that result in a high producing cellular phenotype. These studies may give insights for genetic intervention to possibly create better host cell lines or even to provide clues to more rational strategies for cell line and process development. In this review I will focus on the contribution of proteomic technologies to a greater understanding of the biology of Chinese hamster ovary cells and other producing cell lines such as NS0 mouse cells.
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