Journal
MATERIALS SCIENCE & ENGINEERING C-BIOMIMETIC AND SUPRAMOLECULAR SYSTEMS
Volume 27, Issue 3, Pages 595-598Publisher
ELSEVIER
DOI: 10.1016/j.msec.2006.05.044
Keywords
gene delivery; dextran-spermine; cationic polysaccharide; plasmid complex; in vivo gene delivery
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Cationic polysaccharides were synthesized by conjugation of various oligoamines including monoquatemary ammonium oligoamines and spermine to oxidized dextran by reductive amination and tested for gene transfection. Monoquatemary ammonium polycations were expected to strongly complex DNA due to increased surface cationic charge of the carrier which may result in a higher transfection yield. However, the transfection yields were much lower compared to the parent vector, dextran-spermine conjugate, which was highly effective both in vitro and in vivo. Modification of dextran-spermine conjugate with increasing amounts of the oleic acid and MPEG resulted in high gene transfection in vivo. (c) 2006 Published by Elsevier B.V.
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