Journal
PURE AND APPLIED CHEMISTRY
Volume 79, Issue 4, Pages 685-700Publisher
WALTER DE GRUYTER GMBH
DOI: 10.1351/pac200779040685
Keywords
discodermolide; boron aldol reaction; isolation; side products; olefination
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The novel polyketide (+)-discodermolide was isolated in very small quantities from sponge extracts. This compound is one of several microtubule stabilizers showing promise as novel chemotherapeutic agents for the treatment of cancer. The clinical evaluation of this and similar compounds is hampered by lack of material, and at present, the only way to obtain the necessary quantities is total chemical synthesis.
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