Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 311, Issue 1, Pages 255-258Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2006.10.1161
Keywords
gold; iron-oxide; composite nanoparticle; magnetic separation; oligonucleotide
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Magnetic composite nanoparticles of gold and iron-oxide synthesized with gamma-rays or ultrasonics were functionalized with thiol-modified oligonucleotides. The amount of oligonucleotides bound to the functionalized nanoparticle probes via hybridization was quantified with fluorescently-labeled target oligonucleotides. Our composite nanoparticles magnetically separated the specific target oligonucleotides without the non-specific adsorption. (c) 2006 Elsevier B.V. All rights reserved.
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