Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 311, Issue 1, Pages 84-87Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2006.10.1170
Keywords
magnetic carrier; biodegradable; magnetic target drug delivery; magnetite
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This paper describes a single emulsion-solvent evaporation protocol to prepare PEGylated biodegradable/biocompatible magnetic carriers by utilizing hydrophobic magnetite and a mixture of poly(D,L lactide-co-glycolide) (PLGA) and poly(lactic acid-block-polyethylene glycol) (PLA-PEG) (26:1 by mass) polymers. We characterized the magnetic microspheres in terms of morphology, composite microstructure, size and size distribution, and magnetic properties. Results show that the preparation produces magnetic microspheres with a good spherical morphology, small size (mean diameter of 1.2-1.5 mu m) by means of large size distributions, and magnetizations up to 20-30 emu/g of microspheres. (C) 2006 Elsevier B.V. All rights reserved.
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