Journal
JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Volume 311, Issue 1, Pages 181-186Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.jmmm.2006.10.1151
Keywords
magnetic nanoparticle; hyperthermia; antibody conjugation; specific power absorption rate; cancer therapy; alternating magnetic field
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Bionized nanoferrite (BNF) particles with high specific power absorption rates were synthesized in the size range of 20-100 nm by high-pressure homogenization for targeted cancer therapy with alternating magnetic fields. Several strategies were used to conjugate antibodies to the BNF particles. These strategies were compared using an immunoassay to find optimal conditions to reach a high immuno reactivity of the final antibody-particle conjugate. (C) 2006 Elsevier B.V. All rights reserved.
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