Journal
JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS
Volume 50, Issue 5-6, Pages 303-307Publisher
JOHN WILEY & SONS LTD
DOI: 10.1002/jlcr.1217
Keywords
drug metabolism; isotope labelling; substituted anilines; metabonomics; metabolomics
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Isotopic enrichment of compounds dosed in drug metabolism studies greatly enhances the spectroscopic differentiation of xenobiotic and endogenous metabolites. We show the application of (CN)-C-13-N-15 labelling of a model drug (4-cyanoaniline) as an aid to metabonomic studies of UPLC-MS-generated metabolic data sets. Copyright (c) 2007 John Wiley & Sons, Ltd.
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