Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 35, Issue -, Pages 295-299Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST0350295
Keywords
antizyme; anlizyme inhibitor; ornithine decarboxylase (ODC); putrescine; spermidine; spermidine/spermine-N-1-acetyltransferase (SSAT)
Categories
Funding
- NCI NIH HHS [R01 CA018138, CA18138] Funding Source: Medline
- NIGMS NIH HHS [GM26290] Funding Source: Medline
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Studies over many years have suggested that increased polyamine synthesis may be necessary for neoplastic growth. This review summarizes recent work on the regulation of putrescine production both de novo and via the degradation of higher polyamines and provides a summary of studies using transgenic mice in which the levels of proteins that regulate these processes (L-ornithine decarboxylase, antizyme and spermidine/spermine-N-1-acetyltransferase) are altered.
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