Journal
FEBS LETTERS
Volume 581, Issue 7, Pages 1435-1440Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2007.02.071
Keywords
cancer stem cell; side population; Hoechst 33342; glioma
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Using the C6 glioma cell as a paradigm, we found that (i) the clonogenicity of C6 cells is several orders of magnitude higher than the percentage of SP cells; (ii) non-SP cells are able to generate SP cells, and conversely SP cells generate non-SP cells; (iii) non-SP sorted cells behave as tumorigenic cells. Hence, in C6 cells cultured in serum-containing medium, SP cells can be generated from non-SP cells. This dynamic equilibrium explains in C6 cells the maintenance of the SP phenotype with cell passaging and demonstrates the existence of tumorigenic non-SP cells. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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