Journal
FEBS LETTERS
Volume 581, Issue 7, Pages 1509-1513Publisher
WILEY
DOI: 10.1016/j.febslet.2007.03.008
Keywords
carbamylation; albumin; chronic renal failure; polymorphonuclear neutrophils; (r)espiratory burst
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Carbamylation is a post-translational modification of proteins characterized by the binding of cyanate to amino groups, increased in renal failure. Pathophysiological consequences of carbamylation and adverse effects of carbamylated proteins on cell functions are poorly understood. We studied the influence of carbamylated albumin on polymorphonuclear neutrophil (PMN) O-2(-) production. Carbamylated albumin significantly decreased O-2(-) production in PMNs stimulated by type I collagen, but not by phorbol 12-myristate 13-acetate or tumor necrosis factor-alpha. This effect was related to inhibition of P(125)FAK phosphorylation. Such an alteration of neutrophil oxidative functions might explain characteristic complications of renal failure, such as increased occurrence of inflammation or infections. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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