Journal
INTERNATIONAL JOURNAL OF PHARMACEUTICS
Volume 334, Issue 1-2, Pages 15-26Publisher
ELSEVIER
DOI: 10.1016/j.ijpharm.2007.01.037
Keywords
interpolymer complexes; mucoadhesion; solid drug dispersions; multilayered materials; nanoparticles; in situ gelling systems
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Association of poly(carboxylic acids) and non-ionic polymers in solutions via hydrogen bonding results in formation of novel polymeric materials-interpolymer complexes. These materials can potentially be used for design of novel mucoadhesive dosage forms, development of solid drug dispersions and solubilisation of poorly soluble drugs, encapsulation technologies, preparation of nanoparticles, hydrogels, in situ gelling systems and electrically erodible materials. This review is an attempt to analyse and systematise existing literature on pharmaceutical application of hydrogen-bonded interpolymer complexes. (c) 2007 Elsevier B.V All rights reserved.
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