Journal
JOURNAL OF MEDICINAL CHEMISTRY
Volume 50, Issue 7, Pages 1675-1684Publisher
AMER CHEMICAL SOC
DOI: 10.1021/jm0610292
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Funding
- Ministry of Education, Science & Technology (MoST), Republic of Korea [KGM2170711] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- National Research Foundation of Korea [2006-02662] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Structural modification of a compound discovered during screening using an HRE-dependent reporter assay has revealed a novel class of HIF-1 inhibitors, which potently inhibit the HIF-1 alpha protein accumulation and its target gene expression under hypoxic conditions in human hepatocellular carcinoma Hep3B cells.
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