Journal
AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS
Volume 144B, Issue 3, Pages 361-364Publisher
WILEY
DOI: 10.1002/ajmg.b.30431
Keywords
dystonia; obsessive-compulsive disorder; psychiatric manifestations; variable expressivity; pleiotropy
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Funding
- NINDS NIH HHS [R01-NS26656, R01 NS026656] Funding Source: Medline
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Prior studies suggest that obsessive-compulsive symptoms (OCS) and disorder (OCD) are comorbid with dystonia. We tested if OCS/OCD is a clinical manifestation of the DYT1 dystonia mutation by interviewing members of families with an identified DYT1 mutation, and classifying by manifesting carriers (MC), non-manifesting carriers (NMC), and non-carriers (NC). We found that OCD/OCS are not increased in DYT1 mutation carriers compared with NC, nor is OCD associated with manifesting DYT1 dystonia. (c) 2006 Wiley-Liss, Inc.
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