Journal
SCIENCE
Volume 316, Issue 5821, Pages 112-115Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1137045
Keywords
-
Categories
Funding
- NHGRI NIH HHS [P50 HG002790, 5T32 HG002536] Funding Source: Medline
- NIGMS NIH HHS [R01 GM063056-06, R01 GM063056] Funding Source: Medline
- PHS HHS [063056] Funding Source: Medline
Ask authors/readers for more resources
The domestic dog exhibits greater diversity in body size than any other terrestrial vertebrate. We used a strategy that exploits the breed structure of dogs to investigate the genetic basis of size. First, through a genome-wide scan, we identified a major quantitative trait locus (QTL) on chromosome 15 influencing size variation within a single breed. Second, we examined genetic variation in the 15-megabase interval surrounding the QTL in small and giant breeds and found marked evidence for a selective sweep spanning a single gene (IGF1), encoding insulin-like growth factor 1. A single IGF1 single-nucleotide polymorphism haplotype is common to all small breeds and nearly absent from giant breeds, suggesting that the same causal sequence variant is a major contributor to body size in all small dogs.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available