Journal
BRAIN RESEARCH
Volume 1140, Issue -, Pages 161-169Publisher
ELSEVIER
DOI: 10.1016/j.brainres.2006.05.105
Keywords
development; cerebellum; swaying mutant; vermis; catenin; Wnt1
Categories
Ask authors/readers for more resources
Because of the failure to form embryonic mid-hindbrain structures in conventional Wnt1 knockout animals, ongoing roles for Wnt signaling at later stages have been difficult to resolve. Here, we used Nestin-cre to ablate beta-catenin at midgestation in developing CNS precursors to investigate beta-catenin-dependent Writ signaling in the development of late-derived structures such as the cerebellum. At 14.5 dpc, we found evidence for premature neural precursor cell fate commitment. At PO, we observed vermian hypoplasia and failure to fuse the cerebellar hemispheres and caudal midbrain, a phenotype reminiscent of the swaying (Wnt1(sw/sw)) mouse mutant. Our findings indicate general functions for beta-catenin beyond the neural plate stage during brain development and a particular role for beta-catenindependent Writ signaling during morphogenesis of the caudal midbrain and the cerebellum. We discuss our results with respect to genetic pathways that regulate formation of derivatives of the embryonic midbrain-hindbrain region. (c) 2006 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available